AbstractIn this article we present a general approach not relying on item response theory models (non-IRT) to detect differential item functioning (DIF) in dichotomous items with presence of guessing. The proposed nonlinear regression (NLR) procedure for DIF detection is an extension of method based on logistic regression. As a non-IRT approach, NLR can be seen as a proxy of detection based on the three-parameter IRT model which is a standard tool in the study field. Hence, NLR fills a logical gap in DIF detection methodology and as such is important for educational purposes. Moreover, the advantages of the NLR procedure as well as comparison to other commonly used methods are demonstrated in a simulation study. A real data analysis is offered to demonstrate practical use of the method.